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讲准字225号:Cellular toxicity of nanoparticles/ Measurement of mycotoxin exposure in human populations using biomarkers of exposure

講座報告主題:Cellular toxicity of nanoparticles/ Measurement of mycotoxin exposure in human populations using biomarkers of exposure  
專家姓名:Michael Norman Routledge
日期:2019-09-19 時間:9:30
地點:會議中心第三報告廳
主辦單位:食品與生物工程學院  

主講簡介:Michael Norman Routledge1991年畢業于約克大學,獲環境致癌作用專業博士學位,長期從事食品衛生的教學和科研工作,研究方向主要爲食品黴菌毒素的安全性評價和人群預防措施。科研工作主要著眼于食品化學汙染物的暴露測量和人體健康效應評價。作爲學科領域的學術帶頭人,先後承擔國際研究項目12項,在國際該領域雜志上發表論文近80篇,參與著書7冊。研究工作被許多國際權威機構引用論證真菌毒素的健康風險。其科研工作得到英國皇家學會、英國政府、比爾蓋茨基金會等的大力資助。研究專長:食品毒理學。

主講內容:“Cellular toxicity of nanoparticles”Engineered nanoparticles are used in many food products and can also enter the environment, leading to potential exposure through ingestion, inhalation or absorption. As part of a European collaboration called ENNSATOX, SiO2, TiO2 and ZnO nanoparticles of varying size and morphology were tested for toxicity. In this seminar the results of toxicity and genotoxicity tests on cultured colon, skin and lung cells will be described. In addition to comparing size and shape on toxicity, the mechanism of cellular uptake of silica nanoparticles was determined using electron microscopy. Nano and ultrafine particles are also produced during combustion, and are key components of air pollution in urban environments. Evidence of the increased toxicity of ultrafine particulate matter collected at the roadside on lung cells, and the impact of these particulates on vascular endothelial cells will also be presented. “Measurement of mycotoxin exposure in human populations using biomarkers of exposure”There are a number of mycotoxins that have potential to impact on human health, including aflatoxin, fumonisins and deoxynivalenol. Of these, aflatoxin is the most potent and is known to cause acute illness as well as be carcinogenic. We have used biomarkers to assess individual exposure to these toxins in order to assess their potential health effects in epidemiological studies. In this seminar, the biomarker methods will be described, as well as data being presented from studies in African populations, where the impact of mycotoxin exposure is high.


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